SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

Min Li; Xiaohua Xu; Chou-Wei Chang; Li Zheng; Binghui Shen; Yilun Liu

doi:10.1038/s41467-018-05236-y

Nature Communications (Jul 2018)

SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

Min Li,
Xiaohua Xu,
Chou-Wei Chang,
Li Zheng,
Binghui Shen,
Yilun Liu

Affiliations

Min Li: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Xiaohua Xu: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Chou-Wei Chang: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Li Zheng: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Binghui Shen: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Yilun Liu: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope

DOI: https://doi.org/10.1038/s41467-018-05236-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Transcription-replication conflicts need to be resolved to minimize genome instability. Here the authors show that SUMO2-conjugated PCNA destabilizes RNAPII from chromatin, enhances replication progression and limits transcription-induced DNA damage at common fragile sites.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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