Recent Advances in the Synthesis of Rosettacin

Xiao Tang; Yukang Jiang; Liangliang Song; Erik V. Van der Eycken

doi:10.3390/molecules29102176

Molecules (May 2024)

Recent Advances in the Synthesis of Rosettacin

Xiao Tang,
Yukang Jiang,
Liangliang Song,
Erik V. Van der Eycken

Affiliations

Xiao Tang: College of Science, Nanjing Forestry University, Nanjing 210037, China
Yukang Jiang: College of Science, Nanjing Forestry University, Nanjing 210037, China
Liangliang Song: Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Erik V. Van der Eycken: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium

DOI: https://doi.org/10.3390/molecules29102176
Journal volume & issue: Vol. 29, no. 10
p. 2176

Abstract

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Camptothecin and its analogues show important antitumor activity and have been used in clinical studies. However, hydrolysis of lactone in the E ring seriously attenuates the antitumor activity. To change this situation, aromathecin alkaloids are investigated in order to replace camptothecins. Potential antitumor activity has obtained more and more attention from organic and pharmaceutical chemists. As a member of the aromathecin alkaloids, rosettacin has been synthesized via different methods. This review summarizes recent advances in the synthesis of rosettacin.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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