Respiratory Research (Mar 2024)

The role of sialidase Neu1 in respiratory diseases

  • Shiran Mei,
  • Dingding Li,
  • Aoyi Wang,
  • Guoxue Zhu,
  • Bingwen Zhou,
  • Nian Li,
  • Yi Qin,
  • Yanliang Zhang,
  • Shujun Jiang

DOI
https://doi.org/10.1186/s12931-024-02763-9
Journal volume & issue
Vol. 25, no. 1
pp. 1 – 8

Abstract

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Abstract Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a variety of cellular processes, including cellular signaling and inflammation. In recent years, numerous evidence has suggested that human NEU1 is also involved in the pathogenesis of various respiratory diseases, including lung infection, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. This review paper aims to provide an overview of the current research on human NEU1 and respiratory diseases.