Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

Abstract

α-Tertiary amides are common in bioactive natural products and pharmaceuticals, but challenging to access by conventional methods. Here, the authors report a single-step approach toward α-tertiary amides via cobalt-catalyzed intermolecular oxidative hydroamidation of unactivated alkenes.