Nature Communications (Apr 2021)
Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
- Guanhua Zhu,
- Yu A. Guo,
- Danliang Ho,
- Polly Poon,
- Zhong Wee Poh,
- Pui Mun Wong,
- Anna Gan,
- Mei Mei Chang,
- Dimitrios Kleftogiannis,
- Yi Ting Lau,
- Brenda Tay,
- Wan Jun Lim,
- Clarinda Chua,
- Tira J. Tan,
- Si-Lin Koo,
- Dawn Q. Chong,
- Yoon Sim Yap,
- Iain Tan,
- Sarah Ng,
- Anders J. Skanderup
Affiliations
- Guanhua Zhu
- Genome Institute of Singapore (GIS), A*STAR
- Yu A. Guo
- Genome Institute of Singapore (GIS), A*STAR
- Danliang Ho
- Genome Institute of Singapore (GIS), A*STAR
- Polly Poon
- Genome Institute of Singapore (GIS), A*STAR
- Zhong Wee Poh
- Genome Institute of Singapore (GIS), A*STAR
- Pui Mun Wong
- Genome Institute of Singapore (GIS), A*STAR
- Anna Gan
- Genome Institute of Singapore (GIS), A*STAR
- Mei Mei Chang
- Genome Institute of Singapore (GIS), A*STAR
- Dimitrios Kleftogiannis
- Genome Institute of Singapore (GIS), A*STAR
- Yi Ting Lau
- Genome Institute of Singapore (GIS), A*STAR
- Brenda Tay
- National Cancer Center Singapore
- Wan Jun Lim
- National Cancer Center Singapore
- Clarinda Chua
- National Cancer Center Singapore
- Tira J. Tan
- National Cancer Center Singapore
- Si-Lin Koo
- National Cancer Center Singapore
- Dawn Q. Chong
- National Cancer Center Singapore
- Yoon Sim Yap
- National Cancer Center Singapore
- Iain Tan
- Genome Institute of Singapore (GIS), A*STAR
- Sarah Ng
- Genome Institute of Singapore (GIS), A*STAR
- Anders J. Skanderup
- Genome Institute of Singapore (GIS), A*STAR
- DOI
- https://doi.org/10.1038/s41467-021-22463-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is predictive of ctDNA burden.
