Effects of Ivermectin on some neurochemical parameters and histological changes in chicks

Abstract

The study's goal was to detect the toxic effects of Ivermectin on the liver enzyme activity levels and the concentration of glutamate and glycine in the plasma in the histological section of the brain in chicks. The activity of liver enzymes and the concentration of glutamate and glycine in the plasma were measured as histological sections of the brain were taken after treating the chicks with Ivermectin at a dose of 131.5, 263.0 and 394.5 mg/kg orally after 24 hours of treatment, and the concentration of glutamate and glycine was measured after 5 days of Ivermectin treated at 26.3, 52.6 and 105.2 mg/kg orally. Ivermectin had no toxic effect on the activity of liver enzymes, but its activity was within the normal range in poultry. Ivermectin at doses 131.5, 263, and 394.5mg/kg caused a significant decrease in the plasma concentration of glutamate, while the concentration of glycine was insignificant. Ivermectin had a moderately toxic and rapid effect on the brain through the presence of edema, infiltration of inflammatory cells, vacuolar degeneration of neurons, and their size shrinkage. The dose of 26.3 mg/kg caused a significant decrease in glutamate concentration companies and a significant increase in glycine concentration. The results proved that Ivermectin has a safe effect on the liver by not affecting its enzymes, and it has a moderately toxic effect on the brain tissue represented by (edema, infiltration of inflammatory cells, and vacuolar degeneration), in addition to its effect on the concentration of glutamate and glycine in the plasma.

Keywords

• ivermectin
• histological
• glutamate
• glycine
• chicks