Preparation and development of polyherbal formulation of medicinal plants for antiarthritic activity

Abstract

AIM AND OBJECTIVES: The main objective of the present research was to prepare and develop polyherbal formulation of medicinal plants such as seed coat and kernel of Terminalia chebula and Terminalia bellirica and dried fruits of Emblica officinalisand evaluate the antiarthritic activity using animal models. MATERIALS AND METHODS: Using seed coat and kernel of T. chebula and T. bellirica and dried fruits of E. officinalis, Polyherbal formulation was prepared. Further antiarthritic activity of the prepared formulation was tested in female Wistar rats, using Freund's complete adjuvant as an inducing agent. RESULTS: The antiarthritic activity of polyherbal formulation against Freund's complete adjuvant-induced paw edema shows that all the three doses 250, 500, and 750 mg/kg p.o have significant effects and markedly reduced the swelling of paw. CONCLUSION: Polyherbal formulation exerts a significant protective effect against Freund's complete adjuvant-induced paw edema in rats.

Keywords

• antiarthritic activity
• freund's complete adjuvant
• polyherbal formulation