m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

Yuanhui Mao; Leiming Dong; Xiao-Min Liu; Jiayin Guo; Honghui Ma; Bin Shen; Shu-Bing Qian

doi:10.1038/s41467-019-13317-9

Nature Communications (Nov 2019)

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

Yuanhui Mao,
Leiming Dong,
Xiao-Min Liu,
Jiayin Guo,
Honghui Ma,
Bin Shen,
Shu-Bing Qian

Affiliations

Yuanhui Mao: Division of Nutritional Sciences, Cornell University
Leiming Dong: Division of Nutritional Sciences, Cornell University
Xiao-Min Liu: Division of Nutritional Sciences, Cornell University
Jiayin Guo: State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University
Honghui Ma: Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Bin Shen: State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University
Shu-Bing Qian: Division of Nutritional Sciences, Cornell University

DOI: https://doi.org/10.1038/s41467-019-13317-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Several functions have been proposed for m6A in RNA metabolism, yet little is known regarding the specific functions of individual m6A readers. Here, the authors observe that the m6A reader YTHDC2 — which contains an RNA helicase domain — acts on the coding region to promotes mRNA translation by resolving secondary structures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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