Production of interferon-γ by natural killer cells and aging in chronic human schistosomiasis

Abstract

BACKGROUNG: Aging is associated with several alterations in the phenotype, repertoire and activation status of lymphocytes as well as in the cytokine profile produced by these cells. As a lifelong condition, chronic parasitic diseases such as human schistosomiasis overlaps with the aging process and no systematic study has yet addressed the changes in immune response during infection with Schistosoma mansoni in older individuals.

Keywords

• Interferon-γ
• Aging
• Natural killer
• Schistosomiais.