Nature Communications (Jun 2018)

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

  • Hélène Choquet,
  • Seyyedhassan Paylakhi,
  • Stephen C. Kneeland,
  • Khanh K. Thai,
  • Thomas J. Hoffmann,
  • Jie Yin,
  • Mark N. Kvale,
  • Yambazi Banda,
  • Nicholas G. Tolman,
  • Pete A. Williams,
  • Catherine Schaefer,
  • Ronald B. Melles,
  • Neil Risch,
  • Simon W. M. John,
  • K. Saidas Nair,
  • Eric Jorgenson

DOI
https://doi.org/10.1038/s41467-018-04555-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Primary open-angle glaucoma (POAG) leads to progressive vision loss. Here, Choquet et al. perform genome-wide association analysis for POAG in a multi-ethnic cohort, identify a total of nine novel genetic loci and show relevant function of FMNL2 and LMX1B using cell line and mouse experiments.