Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Leopold Kong; Linling He; Natalia de Val; Nemil Vora; Charles D. Morris; Parisa Azadnia; Devin Sok; Bin Zhou; Dennis R. Burton; Andrew B. Ward; Ian A. Wilson; Jiang Zhu

doi:10.1038/ncomms12040

Nature Communications (Jun 2016)

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Leopold Kong,
Linling He,
Natalia de Val,
Nemil Vora,
Charles D. Morris,
Parisa Azadnia,
Devin Sok,
Bin Zhou,
Dennis R. Burton,
Andrew B. Ward,
Ian A. Wilson,
Jiang Zhu

Affiliations

Leopold Kong: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Linling He: Department of Immunology and Microbial Science, The Scripps Research Institute
Natalia de Val: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Nemil Vora: Department of Immunology and Microbial Science, The Scripps Research Institute
Charles D. Morris: Department of Immunology and Microbial Science, The Scripps Research Institute
Parisa Azadnia: Department of Immunology and Microbial Science, The Scripps Research Institute
Devin Sok: International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute
Bin Zhou: Department of Chemistry, The Scripps Research Institute
Dennis R. Burton: International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute
Andrew B. Ward: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Ian A. Wilson: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Jiang Zhu: Department of Integrative Structural and Computational Biology, The Scripps Research Institute

DOI: https://doi.org/10.1038/ncomms12040
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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A major goal of HIV-1 vaccine development is to produce antigens that can induce broadly neutralizing antibodies. Here the authors examine the underlying causes of HIV-1 envelope metastability and design uncleaved, prefusion-optimized gp140 trimers with potential for use as HIV-1 vaccine antigens.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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