Menopause Review (Feb 2010)

Ocena 10-letniego ryzyka złamań u kobiet po menopauzie z wykorzystaniem algorytmu FRAX™, znormalizowanego dla populacji Włoch, Hiszpanii i Wielkiej Brytanii

  • Elżbieta Skowrońska-Jóźwiak,
  • Agata Wójcicka,
  • Roman S. Lorenc,
  • Andrzej Lewiński

Journal volume & issue
Vol. 14, no. 1
pp. 17 – 22

Abstract

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Introduction: Taking into consideration the growing incidence of osteoporotic fractures, identification of patientswith the highest fracture risk seems to be the most rational and cost-effective solution of this clinical problem.The fracture risk assessment tool (FRAX) is a new diagnostic method, proposed by the World Health Organizationand designed for 10-year fracture risk evaluation; there is no Polish version of the FRAX calculator yet. Objectives: Assessment of 10-year fracture risk scores in postmenopausal women of the Lodz population,based on the FRAX algorithm, standardised for the populations of Italy, Spain and the UK. Material and methods: The study group included 94 postmenopausal females (55-80), divided into five agesubgroups. The patients completed a questionnaire form, designed to analyze osteoporosis risk factors, andwere then submitted to femoral neck densitometry by a DXA (dual energy X-ray absorptiometry) scanner (LunarEXPERT). The 10-year fracture risk was assessed by the FRAX method, using a calculator standardised for the populationsof Italy, Spain and the UK. FRAX major (the risk of main osteoporotic fractures) and FRAX hip (the riskof femoral neck fractures) were calculated, using obtained densitometric results (FMD, FHD) and BMI (FM, FH). Results: In each age subgroup, the highest scores of 10-year fracture risk (FRAX major, FRAX hip) were obtained,using the UK-oriented calculator, while the lowest ones were found applying the calculator standardisedfor Spain. The differences were statistically significant and affected patient qualification for therapy vs. establishedintervention threshold. Conclusions: 1. The outcome supports the need for a Polish FRAX calculator with a properly adapted interventionthreshold. 2. It is fairly justified to use the British calculator option until the Polish FRAX version isavailable.

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