Evaluation of the level of the inflammatory factor interleukin-6 in patients with polycystic ovaries and insulin resistance

Abstract

Polycystic ovarian syndrome (PCOS) is a prevalent endocrine disease, with a rate of 6%–20% among females of reproductive age, according to the diagnostic criteria represented by the high male hormone, irregular menstruation, imbalances in hormones, and metabolic disorders. Insulin resistance (IR) is an imbalance in the amount of insulin secreted. This raises the danger of type 2 diabetes and heart disease. Evaluate the inflammatory factor (interleukin-6 [IL-6]) in the serum of those with IR and PCOS and its comparison with the control group. A case and control study included 80 females of reproductive age (16–40) years; 40 females had IR and polycystic ovary syndrome taken as the first group, as for the second group included 40 healthy women. Every sample was taken between October 2022 and February 2023. The following analysis was done (IL-6). The study’s findings showed a difference in the biostatistics of the level of IL-6 between the PCOS and IR group with the control group, as well as when compared in the group of patients in terms of age, it showed the correlation factor between IL-6 and IR. It was found that the level of IL in those with PCOS and IR was higher than the control group, as well as the increase in age in the group of patients, the level of IL-6 increased, and it showed that there was no significant value between IL-6 and IR.

Keywords

• insulin resistance
• interleukin-6
• polycystic ovarian syndrome