Nature Communications (Nov 2022)

EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis

  • Ayushi Verma,
  • Akhilesh Singh,
  • Manish Pratap Singh,
  • Mushtaq Ahmad Nengroo,
  • Krishan Kumar Saini,
  • Saumya Ranjan Satrusal,
  • Muqtada Ali Khan,
  • Priyank Chaturvedi,
  • Abhipsa Sinha,
  • Sanjeev Meena,
  • Anup Kumar Singh,
  • Dipak Datta

DOI
https://doi.org/10.1038/s41467-022-35059-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 22

Abstract

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Enhancer of zeste homolog 2 (EZH2) has been associated with poor prognosis in triple negative breast cancer (TNBC). Here, the authors suggest a potential role for trimethylation function of EZH2 in driving peritoneal metastasis in TNBC.