A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients

David L Sigalet; Dragan Kravarusic; Decker Butzner; Bolette Hartmann; Jens J Holst; Jon Meddings

doi:10.1155/2013/460958

Canadian Journal of Gastroenterology (Jan 2013)

A Pilot Study Examining the Relationship among Crohn Disease Activity, Glucagon-Like Peptide-2 Signalling and Intestinal Function in Pediatric Patients

David L Sigalet,
Dragan Kravarusic,
Decker Butzner,
Bolette Hartmann,
Jens J Holst,
Jon Meddings

Affiliations

David L Sigalet: Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Deparment of Surgery, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Dragan Kravarusic: Deptartment of Surgery, University of Tel Aviv, Tel Aviv, Israel
Decker Butzner: Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Deparment of Surgery, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Bolette Hartmann: Panum Institute, University of Copenhagen, Copenhagen, Denmark
Jens J Holst: Panum Institute, University of Copenhagen, Copenhagen, Denmark
Jon Meddings: Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Deparment of Surgery, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

DOI: https://doi.org/10.1155/2013/460958
Journal volume & issue: Vol. 27, no. 10
pp. 587 – 592

Abstract

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BACKGROUND/OBJECTIVES: The relationship between the enteroendocrine hormone glucagon-like peptide 2 (GLP-2) and intestinal inflammation is unclear. GLP-2 promotes mucosal growth, decreases permeability and reduces inflammation in the intestine; physiological stimulation of GLP-2 release is triggered by nutrient contact. The authors hypothesized that ileal Crohn disease (CD) affects GLP-2 release.

Published in Canadian Journal of Gastroenterology

ISSN: 0835-7900 (Print); 1916-7237 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://onlinelibrary.wiley.com/journal/1720

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