Clinical and Biomedical Research (Nov 2023)

Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty

  • Victor Elias Titonelli ,
  • Douglas Mello Pavão,
  • Pedro Purita Paes Leme ,
  • Renan Teixeira Lobo Teixeira Lobo ,
  • Rodrigo Sattamini Pires e Albuquerque,
  • Eduardo Branco de Sousa

Journal volume & issue
Vol. 43, no. 3

Abstract

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Objective: To evaluate the efficacy of multiple doses of tranexamic acid (TXA) in blood loss in patients undergoing total knee arthroplasty (TKA). Methods: Seven patients of both genders over 50 years old undergoingTKA, who received 15 mg/kg intravenous (IV) TXA 30 minutes before the surgical incision and another 3 doses thereafter were included in this report. Blood loss analysis included blood loss at the drain, hemoglobin loss, and estimated blood loss. Statistical analysis was performed. Results: There was a significant hemoglobin drop after 48 hours, compared to preoperative. Mean blood loss assessed by drain was 20.0 ± 25.17 mL after 24 h. Estimated blood loss was higher after 48 hours compared to 24 hours. No complications were reported in this sample, and no patient received transfusions. Conclusion: The use of TXA in multiple doses did not prevent the drop in postoperative hemoglobin levels and did not correlate with increased complications.

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