Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae

Mohamed-Elamir  F. Hegazy; Ahmed  R. Hamed; Mahmoud  A. A. Ibrahim; Zienab Talat; Eman  H. Reda; Nahla  S. Abdel-Azim; Faiza  M. Hammouda; Seikou Nakamura; Hisashi Matsuda; Eman  G. Haggag; Paul  W. Paré; Thomas Efferth

doi:10.3390/molecules23092221

Molecules (Sep 2018)

Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae

Mohamed-Elamir F. Hegazy,
Ahmed R. Hamed,
Mahmoud A. A. Ibrahim,
Zienab Talat,
Eman H. Reda,
Nahla S. Abdel-Azim,
Faiza M. Hammouda,
Seikou Nakamura,
Hisashi Matsuda,
Eman G. Haggag,
Paul W. Paré,
Thomas Efferth

Affiliations

Mohamed-Elamir F. Hegazy: Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt
Ahmed R. Hamed: Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt
Mahmoud A. A. Ibrahim: Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
Zienab Talat: Phytochemistry Lab., National Organization for Drug Control and Research, Giza 12622, Egypt
Eman H. Reda: Phytochemistry Lab., National Organization for Drug Control and Research, Giza 12622, Egypt
Nahla S. Abdel-Azim: Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt
Faiza M. Hammouda: Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt
Seikou Nakamura: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
Hisashi Matsuda: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
Eman G. Haggag: Department of Pharmacognosy, Helwan University, Cairo 12622, Egypt
Paul W. Paré: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
Thomas Efferth: Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany

DOI: https://doi.org/10.3390/molecules23092221
Journal volume & issue: Vol. 23, no. 9
p. 2221

Abstract

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Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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