Comprehensive evaluation of adverse effects of host modulatory agents: A critical review

Abstract

Recent advances in study of inflammatory pathways are bringing up new pathways of understanding regarding the bone loss and tissue destruction related to periodontitis. This knowledge, along with the development of novel drugs like host modulatory agents that can inhibit bone loss/destruction, provides us with opportunities to manage not only soft tissue inflammation but also the destructive bone loss occurring during periodontitis. The use of such agents as an adjunct to conventional periodontal therapy, not only minimizes the current periodontal disease severity and improves treatment prognosis, but also reduces future susceptibility to periodontal disease. But there are certain adverse effects secondary to these agents and thus this literature review sheds light on some of these adverse reactions which are known to be caused by these novel drugs

Keywords

• adverse
• bisphosphonates
• doxycycline
• effects
• host
• modulation
• nonsteroidal anti-inflammatory drugs
• response