Nature Communications (Sep 2018)
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes
- Joern Pezoldt,
- Maria Pasztoi,
- Mangge Zou,
- Carolin Wiechers,
- Michael Beckstette,
- Guilhem R. Thierry,
- Ehsan Vafadarnejad,
- Stefan Floess,
- Panagiota Arampatzi,
- Manuela Buettner,
- Janina Schweer,
- Diana Fleissner,
- Marius Vital,
- Dietmar H. Pieper,
- Marijana Basic,
- Petra Dersch,
- Till Strowig,
- Mathias Hornef,
- André Bleich,
- Ulrike Bode,
- Oliver Pabst,
- Marc Bajénoff,
- Antoine-Emmanuel Saliba,
- Jochen Huehn
Affiliations
- Joern Pezoldt
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Maria Pasztoi
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Mangge Zou
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Carolin Wiechers
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Michael Beckstette
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Guilhem R. Thierry
- CNRS, INSERM, CIML, Aix Marseille University
- Ehsan Vafadarnejad
- Helmholtz Institute for RNA-based Infection Research
- Stefan Floess
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Panagiota Arampatzi
- Core Unit Systems Medicine, University of Wuerzburg
- Manuela Buettner
- Institute of Functional and Applied Anatomy, Hannover Medical School
- Janina Schweer
- Department Molecular Infection Biology, Helmholtz Centre for Infection Research
- Diana Fleissner
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- Marius Vital
- Research Group Microbial Interactions and Processes, Helmholtz Centre for Infection Research
- Dietmar H. Pieper
- Research Group Microbial Interactions and Processes, Helmholtz Centre for Infection Research
- Marijana Basic
- Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School
- Petra Dersch
- Department Molecular Infection Biology, Helmholtz Centre for Infection Research
- Till Strowig
- Research Group Microbial Immune Regulation, Helmholtz Centre for Infection Research
- Mathias Hornef
- Institute of Medical Microbiology, RWTH Aachen
- André Bleich
- Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School
- Ulrike Bode
- Institute of Functional and Applied Anatomy, Hannover Medical School
- Oliver Pabst
- Institute of Molecular Medicine, RWTH Aachen
- Marc Bajénoff
- CNRS, INSERM, CIML, Aix Marseille University
- Antoine-Emmanuel Saliba
- Helmholtz Institute for RNA-based Infection Research
- Jochen Huehn
- Department Experimental Immunology, Helmholtz Centre for Infection Research
- DOI
- https://doi.org/10.1038/s41467-018-06423-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance.
