A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells

Kathryn Futrega; Pamela G. Robey; Travis J. Klein; Ross W. Crawford; Michael R. Doran

doi:10.1038/s42003-020-01520-0

Communications Biology (Jan 2021)

A single day of TGF-β1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells

Kathryn Futrega,
Pamela G. Robey,
Travis J. Klein,
Ross W. Crawford,
Michael R. Doran

Affiliations

Kathryn Futrega: National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human Services
Pamela G. Robey: National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human Services
Travis J. Klein: Centre for Biomedical Technologies (CBT), Queensland University of Technology (QUT)
Ross W. Crawford: Centre for Biomedical Technologies (CBT), Queensland University of Technology (QUT)
Michael R. Doran: National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Department of Health and Human Services

DOI: https://doi.org/10.1038/s42003-020-01520-0
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Futrega et al. challenge the long established chondrogenic differentiation protocol used to induce bone marrow-derived stromal cell (BMSC) differentiation which presumes the need for more than 2 weeks of continuous TGF-β1 exposure. Using a micro-pellet model, they show that BMSC differentiation is triggered by a single day of TGF-β1 exposure.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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