Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention

Abstract

Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential for cancer initiation playing a critical role in acquiring three-dimensional (3D) growth properties during transformation. In vivo inhibition of FASN before oncogenic activation prevents tumor development and invasive growth suggesting that FASN could be a potential target for cancer prevention.

Keywords

• fasn
• cancer metabolism
• anchorage-independent growth
• cancer prevention