Nature Communications (May 2019)
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
- Karla Rubio,
- Indrabahadur Singh,
- Stephanie Dobersch,
- Pouya Sarvari,
- Stefan Günther,
- Julio Cordero,
- Aditi Mehta,
- Lukasz Wujak,
- Hector Cabrera-Fuentes,
- Cho-Ming Chao,
- Peter Braubach,
- Saverio Bellusci,
- Werner Seeger,
- Andreas Günther,
- Klaus T. Preissner,
- Malgorzata Wygrecka,
- Rajkumar Savai,
- Dulce Papy-Garcia,
- Gergana Dobreva,
- Mathias Heikenwalder,
- Soni Savai-Pullamsetti,
- Thomas Braun,
- Guillermo Barreto
Affiliations
- Karla Rubio
- Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung Research
- Indrabahadur Singh
- Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung Research
- Stephanie Dobersch
- Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung Research
- Pouya Sarvari
- Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
- Stefan Günther
- Department of Cardiac Development, Max-Planck-Institute for Heart and Lung Research
- Julio Cordero
- Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung Research
- Aditi Mehta
- Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung Research
- Lukasz Wujak
- Faculty of Medicine, Biochemistry Institute, Justus Liebig University
- Hector Cabrera-Fuentes
- Faculty of Medicine, Biochemistry Institute, Justus Liebig University
- Cho-Ming Chao
- Chair for Lung Matrix Remodeling, Excellence Cluster Cardio Pulmonary System, Justus Liebig University
- Peter Braubach
- German Center of Lung Research (Deutsches Zentrum für Lungenforschung, DZL), UGMLC
- Saverio Bellusci
- Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University
- Werner Seeger
- Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
- Andreas Günther
- Member of the Excellence Cluster Cardio Pulmonary System (ECCPS), The Universities of Giessen and Marburg Lung Center (UGMLC)
- Klaus T. Preissner
- Faculty of Medicine, Biochemistry Institute, Justus Liebig University
- Malgorzata Wygrecka
- Faculty of Medicine, Biochemistry Institute, Justus Liebig University
- Rajkumar Savai
- Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
- Dulce Papy-Garcia
- Laboratoire Croissance, Réparation et Régénération Tissulaires (CRRET), CNRS ERL 9215, Université Paris Est Créteil, Université Paris Est
- Gergana Dobreva
- Anatomy and Developmental Biology, CBTM, Heidelberg University
- Mathias Heikenwalder
- Division Chronic Inflammation and Cancer (F180), German Cancer Research Center (DKFZ)
- Soni Savai-Pullamsetti
- Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research
- Thomas Braun
- Department of Cardiac Development, Max-Planck-Institute for Heart and Lung Research
- Guillermo Barreto
- Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung Research
- DOI
- https://doi.org/10.1038/s41467-019-10066-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.
