Nature Communications (May 2020)

Nucleoplasmic signals promote directed transmembrane protein import simultaneously via multiple channels of nuclear pores

  • Krishna C. Mudumbi,
  • Rafal Czapiewski,
  • Andrew Ruba,
  • Samuel L. Junod,
  • Yichen Li,
  • Wangxi Luo,
  • Christina Ngo,
  • Valentina Ospina,
  • Eric C. Schirmer,
  • Weidong Yang

DOI
https://doi.org/10.1038/s41467-020-16033-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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The contribution of central and peripheral channels of nuclear pores to transport of transmembrane proteins is unclear. Here the authors show that most inner nuclear membrane proteins use only peripheral channels, but some extend nuclear localization signals into the central channel for directed nuclear transport.