Premortem diagnosis of pathologically confirmed sporadic Creutzfeldt‐Jakob disease

Abstract

Abstract Sporadic Creutzfeldt‐Jakob disease should be considered in any case of rapid neuropsychiatric decline. While neuropathological examination of a brain biopsy specimen remains the only definitive diagnostic method and real‐time quaking‐induced conversion tests have simplified premortem diagnosis, careful evaluation of magnetic resonance imaging can provide readily accessible clues.

Keywords

• Acute medicine
• genetics
• geriatric medicine
• neurology
• psychiatry