The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells

• Niels Weinhold,
• Tobias Meissner,
• David C Johnson,
• Anja Seckinger,
• Jérôme Moreaux,
• Asta Försti,
• Bowang Chen,
• Jolanta Nickel,
• Daniel Chubb,
• Andrew C. Rawstron,
• Chi Doughty,
• Nasrin B. Dahir,
• Dil B. Begum,
• Kwee Young,
• Brian A. Walker,
• Per Hoffmann,
• Marcus M. Nöthen,
• Faith E. Davies,
• Bernard Klein,
• Hartmut Goldschmidt,
• Gareth J. Morgan,
• Richard S Houlston,
• Dirk Hose,
• Kari Hemminki

Affiliations

Niels Weinhold

Department of Internal Medicine V, University of Heidelberg, Germany

Tobias Meissner

Department of Internal Medicine V, University of Heidelberg, Germany;Department of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA

David C Johnson

Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

Anja Seckinger

Department of Internal Medicine V, University of Heidelberg, Germany

Jérôme Moreaux

INSERM, Unité 1040, Institut de Recherche en Biothérapie, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Avenue Augustin Fliche, 34295 Montpellier, France

Asta Försti

German Cancer Research Center, Heidelberg, Germany;Center for Primary Health Care Research, Lund University, Malmo, Sweden

Bowang Chen

German Cancer Research Center, Heidelberg, Germany

Jolanta Nickel

Department of Internal Medicine V, University of Heidelberg, Germany

Daniel Chubb

Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK

Andrew C. Rawstron

Haematological Malignancy Diagnostic Service Laboratory, St James University Hospital, Leeds, UK

Chi Doughty

Haematological Malignancy Diagnostic Service Laboratory, St James University Hospital, Leeds, UK

Nasrin B. Dahir

Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

Dil B. Begum

Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

Kwee Young

Department of Haematology, University College London Hospital, UK

Brian A. Walker

Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

Per Hoffmann

Institute of Human Genetics, University of Bonn, Germany;Division of Medical Genetics, Department of Biomedicine, University of Basel, Switzerland

Marcus M. Nöthen

Institute of Human Genetics, University of Bonn, Germany;Department of Genomics, Life & Brain Center, University of Bonn, Germany

Faith E. Davies

Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

Bernard Klein

INSERM, Unité 1040, Institut de Recherche en Biothérapie, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Avenue Augustin Fliche, 34295 Montpellier, France

Hartmut Goldschmidt

Department of Internal Medicine V, University of Heidelberg, Germany;National Centre for Tumor Diseases, Heidelberg, Germany

Gareth J. Morgan

Centre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

Richard S Houlston

Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK

Dirk Hose

Department of Internal Medicine V, University of Heidelberg, Germany;National Centre for Tumor Diseases, Heidelberg, Germany

Kari Hemminki

German Cancer Research Center, Heidelberg, Germany;Center for Primary Health Care Research, Lund University, Malmo, Sweden