Nature Communications (Mar 2022)

Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease

  • Hui Sun,
  • Hui Li,
  • Jie Yan,
  • Xiangdong Wang,
  • Mengyuan Xu,
  • Mingxia Wang,
  • Baozhen Fan,
  • Jieying Liu,
  • Ninghua Lin,
  • Xin Wang,
  • Li Li,
  • Shengtian Zhao,
  • Yongfeng Gong

DOI
https://doi.org/10.1038/s41467-022-29277-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Claudin-5 is a tight junction integral membrane protein, but it is also expressed in mature podocytes which lack tight junctions. Here the authors report that podocyte claudin-5 regulates WNT signaling activity by modulating WIF1 expression, and its downregulation contributes to kidney disease progression in mice.