Platelet activating factor acetylhydrolase is associated with cardiac valvular calcification in dialysis patients

Abstract

The cardiovascular mortality risk is greatly increased in patients with chronic kidney disease (CKD), especially in dialysis patients, due to atherosclerosis. Platelet activating factor acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes platelet activating factor (PAF). Valvular calcifications and PAF-AH are associated with atherosclerosis. However, little is known about the status of PAF-AH activity and valvular calcification in dialysis patients. Therefore, the aim of this study was to investigate the status of these parameters in CKD patients.

Keywords

• hemodialysis
• peritoneal dialysis
• calcification
• platelet activating factor acetylhydrolase (paf-ah)
• nt-probnp