EMBO Molecular Medicine (May 2021)
PI3Kα targeting, nipping pancreatic cancer evolution in the bud
Abstract
Abstract Thibault et al (2021) elucidate key signalling events mediating metastatic evolution in pancreatic ductal adenocarcinoma (PDAC) by demonstrating a role of PI3Kα in the regulation of macro‐metastatic disease and a corresponding pro‐tumoural immune response supporting disease progression.