Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report

Abstract

Abstract This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid‐refractory, but second‐line option was abandoned because of cachexia. Further discussions are needed regarding the customized management of immune‐related toxicities.

Keywords

• autopsy
• endothelialitis
• immune checkpoint inhibitors
• immune‐related adverse events
• liver
• necrosis