Investigating the 25(OH) Vitamin D Levels and Impacts of Urinary Tract Infection in Geriatric Hematogenous Septic Arthritis Patients

Abstract

Objective:Our study aimed to determine the serum level of 25(OH) vitamin D in geriatric hematogenous septic arthritis and to assess the potential presence of urinary tract infections in the same cohort.Method:The study included 22 patients diagnosed with septic arthritis and 25 individuals selected to match the control group’s age and gender distribution. Inclusion criteria for patients diagnosed with septic arthritis were the presence of monoarthritis, age over 60, swelling and pain in the joint, high C-reactive protein (CRP) levels, purulent joint fluid, and the presence of more than 50,000 neutrophils per mm³ in the joint fluid or within the joint culture. In both the septic arthritis and control groups, a comprehensive assessment encompassed hemogram, CRP, whole blood biochemistry, complete urinalysis, urine culture, and 25(OH) vitamin D tests for comparative analysis.Results:In the patient group, 25(OH) vitamin D levels were significantly lower than the control group (p0.05).Conclusion:Our study has identified a notable correlation between severe vitamin D deficiency and hematogenous septic arthritis among elderly individuals. Furthermore, evidence of bacteriuria and pyuria emerged in the complete urinalysis of some subjects. These findings support our belief that certain instances of hematogenous geriatric septic arthritis may arise as a consequence of urosepsis.

Keywords

• geriatric
• sepsis
• septic arthritis
• urinary tract infection
• vitamin d