Wnt pathway activation by ADP-ribosylation

Eungi Yang; Ofelia Tacchelly-Benites; Zhenghan Wang; Michael P. Randall; Ai Tian; Hassina Benchabane; Sarah Freemantle; Claudio Pikielny; Nicholas S. Tolwinski; Ethan Lee; Yashi Ahmed

doi:10.1038/ncomms11430

Nature Communications (May 2016)

Wnt pathway activation by ADP-ribosylation

Eungi Yang,
Ofelia Tacchelly-Benites,
Zhenghan Wang,
Michael P. Randall,
Ai Tian,
Hassina Benchabane,
Sarah Freemantle,
Claudio Pikielny,
Nicholas S. Tolwinski,
Ethan Lee,
Yashi Ahmed

Affiliations

Eungi Yang: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College
Ofelia Tacchelly-Benites: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College
Zhenghan Wang: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College
Michael P. Randall: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College
Ai Tian: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College
Hassina Benchabane: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College
Sarah Freemantle: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth College
Claudio Pikielny: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College
Nicholas S. Tolwinski: Department of Biological Sciences, Yale-NUS College, National University of Singapore
Ethan Lee: Department of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, and Vanderbilt Institute of Chemical Biology
Yashi Ahmed: Department of Genetics and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College

DOI: https://doi.org/10.1038/ncomms11430
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling by promoting the interaction between Axin and the Wnt co-receptor LRP6.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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