Use of Anakinra in Patients with Cryopyrin-Associated Periodic Syndromes and Other Autoinflammatory Diseases

Abstract

The article describes the main autoinflammatory syndromes as well as the key role of interleukin (IL) 1 in the pathogenesis of these diseases. It also presents the data on the experience of anakinra using (soluble IL-1 receptor antagonist) as well as the results of randomized clinical trials and descriptions of anakinra use case series in autoinflammatory and a number of other non-rheumatic diseases. The data on the efficacy and safety of a soluble IL-1 receptor antagonist is given.

Keywords

• autoinflammation
• cryopyrin-associated periodic syndromes
• interleukin 1
• soluble il-1 receptor antagonist
• anakinra