Nature Communications (Jan 2021)
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation
- Guangjian Fan,
- Lianhui Sun,
- Ling Meng,
- Chen Hu,
- Xing Wang,
- Zhan Shi,
- Congli Hu,
- Yang Han,
- Qingqing Yang,
- Liu Cao,
- Xiaohong Zhang,
- Yan Zhang,
- Xianmin Song,
- Shujie Xia,
- Baokun He,
- Shengping Zhang,
- Chuangui Wang
Affiliations
- Guangjian Fan
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Lianhui Sun
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Ling Meng
- Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University
- Chen Hu
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Xing Wang
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Zhan Shi
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Congli Hu
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Yang Han
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Qingqing Yang
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Liu Cao
- Key Laboratory of Medical Cell Biology, College of Translational Medicine, China Medical University
- Xiaohong Zhang
- Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine
- Yan Zhang
- Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Xianmin Song
- Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Shujie Xia
- Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; Institute of Urology, Shanghai Jiao Tong University
- Baokun He
- Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Shengping Zhang
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Chuangui Wang
- Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-20208-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased clustering efficiency and tumour recurrence.
