Nature Communications (Apr 2021)
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer
- Takashi Nishina,
- Yutaka Deguchi,
- Daisuke Ohshima,
- Wakami Takeda,
- Masato Ohtsuka,
- Shigeyuki Shichino,
- Satoshi Ueha,
- Soh Yamazaki,
- Mika Kawauchi,
- Eri Nakamura,
- Chiharu Nishiyama,
- Yuko Kojima,
- Satomi Adachi-Akahane,
- Mizuho Hasegawa,
- Mizuho Nakayama,
- Masanobu Oshima,
- Hideo Yagita,
- Kazutoshi Shibuya,
- Tetuo Mikami,
- Naohiro Inohara,
- Kouji Matsushima,
- Norihiro Tada,
- Hiroyasu Nakano
Affiliations
- Takashi Nishina
- Department of Biochemistry, Toho University School of Medicine
- Yutaka Deguchi
- Department of Biochemistry, Toho University School of Medicine
- Daisuke Ohshima
- Department of Physiology, Toho University School of Medicine
- Wakami Takeda
- Department of Biochemistry, Toho University School of Medicine
- Masato Ohtsuka
- Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University
- Shigeyuki Shichino
- Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science
- Satoshi Ueha
- Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science
- Soh Yamazaki
- Department of Biochemistry, Toho University School of Medicine
- Mika Kawauchi
- Department of Biochemistry, Toho University School of Medicine
- Eri Nakamura
- Research Institute for Diseases of Old Age, Juntendo University School of Medicine
- Chiharu Nishiyama
- Laboratory of Molecular Biology and Immunology, Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science
- Yuko Kojima
- Laboratory of Morphology and Image Analysis, Research Support Center, Juntendo University Graduate School of Medicine
- Satomi Adachi-Akahane
- Department of Physiology, Toho University School of Medicine
- Mizuho Hasegawa
- Department of Pathology, University of Michigan Medical School
- Mizuho Nakayama
- WPI Nano Life Science Institute (WPI-Nano LSI), Division of Genetics, Cancer Research Institute, Kanazawa University
- Masanobu Oshima
- WPI Nano Life Science Institute (WPI-Nano LSI), Division of Genetics, Cancer Research Institute, Kanazawa University
- Hideo Yagita
- Department of Immunology, Juntendo University Graduate School of Medicine
- Kazutoshi Shibuya
- Department of Surgical Pathology, Toho University School of Medicine
- Tetuo Mikami
- Department of Pathology, Toho University School of Medicine
- Naohiro Inohara
- Department of Pathology, University of Michigan Medical School
- Kouji Matsushima
- Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science
- Norihiro Tada
- Research Institute for Diseases of Old Age, Juntendo University School of Medicine
- Hiroyasu Nakano
- Department of Biochemistry, Toho University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-22450-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
The stromal fibroblast population in the colon is composed of heterogeneous and distinct cell subtypes that play a crucial role in the development of colitis and colon cancer. Here the authors generate IL-11 reporter mice and characterize the origin and phenotype of inflammatory IL-11+ fibroblasts in colitis and colon cancer preclinical models.
