Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response

Tobias Sahr; Pedro Escoll; Christophe Rusniok; Sheryl Bui; Gérard Pehau-Arnaudet; Gregory Lavieu; Carmen Buchrieser

doi:10.1038/s41467-022-28454-x

Nature Communications (Feb 2022)

Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response

Tobias Sahr,
Pedro Escoll,
Christophe Rusniok,
Sheryl Bui,
Gérard Pehau-Arnaudet,
Gregory Lavieu,
Carmen Buchrieser

Affiliations

Tobias Sahr: Institut Pasteur, Université de Paris, Biologie des Bactéries Intracellulaires and CNRS UMR 6047
Pedro Escoll: Institut Pasteur, Université de Paris, Biologie des Bactéries Intracellulaires and CNRS UMR 6047
Christophe Rusniok: Institut Pasteur, Université de Paris, Biologie des Bactéries Intracellulaires and CNRS UMR 6047
Sheryl Bui: Université de Paris, INSERM ERL U1316, UMR 7057/CNRS
Gérard Pehau-Arnaudet: Unité de Technologie et Service BioImagerie Ultrastructurale and CNRS UMR 3528
Gregory Lavieu: Université de Paris, INSERM ERL U1316, UMR 7057/CNRS
Carmen Buchrieser: Institut Pasteur, Université de Paris, Biologie des Bactéries Intracellulaires and CNRS UMR 6047

DOI: https://doi.org/10.1038/s41467-022-28454-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Legionella pneumophila expresses a range of bacterial determinants that mimic eukaryotic functions. Here the authors show small RNAs of L.pneumophila mimic eukaryotic microRNA and modulate the host response to infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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