Selectivity in multiple multicomponent reactions: types and synthetic applications

Abstract

Multiple multicomponent reactions reach an unparalleled level of connectivity, leading to highly complex adducts. Usually, only one type of transformation involving the same set of reactants takes place. However, in some occasions this is not the case. Selectivity issues then arise, and different scenarios are analyzed. The structural pattern of the reactants, the reaction design and the experimental conditions are the critical factors dictating selectivity in these processes.

Keywords

• isocyanides
• multicomponent reactions
• reaction discovery
• selectivity