Nature Communications (Oct 2020)
Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
- Ulrich Pfisterer,
- Viktor Petukhov,
- Samuel Demharter,
- Johanna Meichsner,
- Jonatan J. Thompson,
- Mykhailo Y. Batiuk,
- Andrea Asenjo-Martinez,
- Navneet A. Vasistha,
- Ashish Thakur,
- Jens Mikkelsen,
- Istvan Adorjan,
- Lars H. Pinborg,
- Tune H. Pers,
- Jakob von Engelhardt,
- Peter V. Kharchenko,
- Konstantin Khodosevich
Affiliations
- Ulrich Pfisterer
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- Viktor Petukhov
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- Samuel Demharter
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- Johanna Meichsner
- Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz
- Jonatan J. Thompson
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Mykhailo Y. Batiuk
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- Andrea Asenjo-Martinez
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- Navneet A. Vasistha
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- Ashish Thakur
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- Jens Mikkelsen
- Department of Neurology and Neurobiology Research Unit, Copenhagen University Hospital
- Istvan Adorjan
- Department of Anatomy, Histology and Embryology, Semmelweis University
- Lars H. Pinborg
- Neurobiology Research Unit, Copenhagen University Hospital
- Tune H. Pers
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Jakob von Engelhardt
- Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz
- Peter V. Kharchenko
- Department of Biomedical Informatics, Harvard Medical School
- Konstantin Khodosevich
- Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-020-18752-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, predicting neuronal circuits contributing to epilepsy.
