Do Weight trajectories influence diabetes control? A prospective study in Switzerland (CoLaus study)

Abstract

Objective: Identify anthropometric trajectories among subjects with type 2 diabetes mellitus (T2DM), and associate them with glycaemic control. Methods: Prospective study including 268 community-dwelling participants with T2DM (34% women, mean age 68.7 ± 8.9 years) followed for 10.7 years (range: 8.8–13.6 years). T2DM control was considered for 1) fasting plasma glucose (FPG) 5 kg, and 25% lost 5 cm. Using FPG as criterion, participants who lost > 5 cm waist were more likely to be controlled: multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI): 3.10 (1.23–7.78). Participants with controlled T2DM also presented with a higher weight variability: multivariable adjusted mean ± standard error 4.8 ± 0.3 vs. 3.9 ± 0.3 kg, p = 0.028. Using HbA1c as criterion, participants who lost > 5 kg were less likely to be controlled: OR and (95% CI): 0.35 (0.18–0.66). Similar findings were obtained when restricting the analysis to participants who were diabetic throughout the whole study period. Conclusion: In a Swiss community-based sample of participants with T2DM, T2DM control rates could be implemented. Neither weight nor waist variability was significantly and consistently associated with T2DM control.

Keywords

• Diabetes
• Diabetes management
• Weight
• Weight variability
• Waist
• Epidemiology