Adaptive designs of clinical trials: An overview

Abstract

The use of adaptive design methods in clinical research has become popular due to its flexibility. Such methods are very useful in early clinical development. Urn designs and covariate-adaptive designs are specific adaptive designs aimed at balancing the treatment groups in a clinical trial. In this article, we provide a comprehensive review of adaptive design methods in clinical research and development.

Keywords

• response-adaptive randomization
• urn design
• covariate-adaptive randomization