P5.33 REVERSE DIPPING STATUS IS INVERSELY ASSOCIATED WITH HEALTH-RELATED QUALITY OF LIFE

Abstract

Objectives: We sought to investigate whether reverse dipping status is associated with self-reported health-related quality of life (HRQOL). Methods: BP was evaluated non-invasively under 24-hour ABPM with a brachial cuff-based automatic oscillometric device (Mobilo-O-Graph, IEM); all subjects maintained a time-log indicating awake/asleep periods. Subjects were classified as Reverse Dippers (Group-A) if SBP-asleep > SBP-awake; the rest were included in Group-B. For HRQOL assessment the EQ5D instrument was utilized prior to BP evaluation. EQ5D estimates the following dimensions: mobility (MO), self-care (SC), usual activities (UA), pain/discomfort (PD), anxiety/depression (AD); each is subdivided in three severity levels (1=no, 2=some/moderate and 3=extreme problems). Moreover, an index (MVH-York-A1-tariff) is calculated by the combination of these dimensions. Additionally, EQ5D involves a visual analogue scale (VAS) in which respondents self-rate their health state (0=worst, 100=best imaginable). Results: Group-A consisted of 10 subjects and Group-B of 139. The two groups were comparable regarding demographic and clinical characteristics (males 50% vs. 53%, 63 vs. 55 years old, BMI 26.5 vs. 27.2, hypertension 60% vs. 48.2%, diabetes mellitus 10% vs. 10%, respectively; p=ns for all). MO, SC, UA, AD and MVH-York-A1-tariff (A: 0.74±0.23 vs. B: 0.86±0.74) did not differ between the two groups. Yet, a higher percentage of Group-A stated some/moderate or severe problems in PD dimension compared to Group-B (Figures A, B; p<0.001). Moreover, lower levels of VAS were observed in Group-A compared to Group-B (72.5±10.9 vs. 78.7±13.7, respectively; p=0.037). Conclusions: In the present study reverse dipping status is associated with lower levels of HRQOL.