Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Marco Bonizzato; Nicholas D. James; Galyna Pidpruzhnykova; Natalia Pavlova; Polina Shkorbatova; Laetitia Baud; Cristina Martinez-Gonzalez; Jordan W. Squair; Jack DiGiovanna; Quentin Barraud; Silvestro Micera; Gregoire Courtine

doi:10.1038/s41467-021-22137-9

Nature Communications (Mar 2021)

Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Marco Bonizzato,
Nicholas D. James,
Galyna Pidpruzhnykova,
Natalia Pavlova,
Polina Shkorbatova,
Laetitia Baud,
Cristina Martinez-Gonzalez,
Jordan W. Squair,
Jack DiGiovanna,
Quentin Barraud,
Silvestro Micera,
Gregoire Courtine

Affiliations

Marco Bonizzato: Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Nicholas D. James: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Galyna Pidpruzhnykova: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Natalia Pavlova: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Polina Shkorbatova: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Laetitia Baud: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Cristina Martinez-Gonzalez: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Jordan W. Squair: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Jack DiGiovanna
Quentin Barraud: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)
Silvestro Micera: Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Gregoire Courtine: Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL)

DOI: https://doi.org/10.1038/s41467-021-22137-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Deep brain stimulation and epidural electrical stimulation of the spinal cord enable locomotion in humans with spinal cord injury (SCI) but the potential synergy between both approaches is unclear. The authors show that a complex technological approach is required to enable volitional walking in rats with SCI.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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