Nature Communications (Sep 2018)

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

  • Frank Lennartz,
  • Florian Brod,
  • Rebecca Dabbs,
  • Kazutoyo Miura,
  • David Mekhaiel,
  • Arianna Marini,
  • Matthijs M. Jore,
  • Max M. Søgaard,
  • Thomas Jørgensen,
  • Willem A. de Jongh,
  • Robert W. Sauerwein,
  • Carole A. Long,
  • Sumi Biswas,
  • Matthew K. Higgins

DOI
https://doi.org/10.1038/s41467-018-06340-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Pfs48/45 is a promising component for a transmission-blocking malaria vaccine. Here, the authors develop a system to produce full-length Pfs48/45 for immunisation, characterise a panel of monoclonal antibodies and determine the structure of a potent transmission-blocking epitope.