Screening and analysis of RNAs associated with activated memory CD4 and CD8 T cells in liver cancer

Abstract

Highlights A total of 309 CD8 T cell-related genes and 120 activated memory CD4 T cell-related genes were screened in liver cancer tumor samples. Forty-four chemical small-molecule–target interaction pairs associated with activated memory CD4 T cells and 276 pairs associated with CD8 T cells were screened. Upregulated expression of T cell-related genes including EOMES, CST7, and CD5L indicated the favorable prognosis of liver cancer.

Keywords

• Liver cancer
• Differentially expressed analysis
• Immune-related genes
• T cells
• Survival analysis
• CeRNA network