精准医学杂志 (Oct 2024)
Efficacy and safety of nalbuphine for dural puncture epidural labor analgesia
Abstract
Objective To investigate the efficacy and safety of nalbuphine for dural puncture epidural labor analgesia. Methods A total of 319 primiparous women with a full-term single fetus who received trial of labor were enrolled, and according to the drug used for analgesia, they were divided into sufentanil group (group A with 160 women) and nalbuphine group (group B with 159 women). The women in both groups were given dural puncture epidural labor analgesia, during which 3 mL of 1.5% lidocaine was injected after epidural catheter placement, and then the women in group A were given injection of 0.5 mg/L sufentanil combined with 1 mg/L ropivacaine, while those in group B were given injection of 0.3 g/L nalbuphine combined with 1 mg/L ropi-vacaine, with an initial volume of 6-15 mL. After 30 minutes, an electronic analgesia pump was connected for both groups, and sufentanil and nalbuphine were used for patient-controlled epidural analgesia, respectively. The following indicators were collected and observed: Onset time of analgesia, time of first patient-controlled analgesia (PCA) pressing, number of effective PCA pres-sings, and amount of ropivacaine used; Visual Analogue Scale (VAS) score and Ramsay sedation score before analgesia (T0), at 30 minutes after analgesia (T1), at the time of uterine opening (T2), and during labor (T3); incidence rates of adverse reactions in parturients, including pyrexia, nausea and vomiting, skin pruritus, and postoperative headache; the incidence rate of fetal heart rate deceleration, the proportion of neonates with 1 min Apgar score ≤7 points, umbilical arterial blood gas analysis, and neonatal neurological and adaptive capacity scores. Results Compared with group A, group B had significant reductions in the incidence rates of vomiting and nausea, skin pruritus, fetal heart rate deceleration, and neonatal 1 min Apgar score ≤7 (χ2=4.159-5.628,P<0.05) and significant increases in the number of effective PCA pressings and the amount of ropivacaine used (χ2=8.594,6.363,P<0.05), as well as a significant increase in VAS score of the parturients at T2 and T3 (F=45.314,26.717,P<0.05), while there were no significant differences in the other indicators between the two groups (P>0.05). Conclusion For dural puncture epidural labor analgesia, nalbuphine has a similar analgesic effect to sufentanil in the first stage of labor, with a poorer effect in the second stage of labor, but it can reduce analgesia-related adverse reactions in parturients and has a relatively favorable safety profile in neonates.
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