Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

Anne Margarete Merks; Marie Swinarski; Alexander Matthias Meyer; Nicola Victoria Müller; Ismail Özcan; Stefan Donat; Alexa Burger; Stephen Gilbert; Christian Mosimann; Salim Abdelilah-Seyfried; Daniela Panáková

doi:10.1038/s41467-018-04566-1

Nature Communications (Jun 2018)

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

Anne Margarete Merks,
Marie Swinarski,
Alexander Matthias Meyer,
Nicola Victoria Müller,
Ismail Özcan,
Stefan Donat,
Alexa Burger,
Stephen Gilbert,
Christian Mosimann,
Salim Abdelilah-Seyfried,
Daniela Panáková

Affiliations

Anne Margarete Merks: Electrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Marie Swinarski: Electrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Alexander Matthias Meyer: Electrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Nicola Victoria Müller: Electrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Ismail Özcan: Electrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Stefan Donat: Institute for Biochemistry and Biology, Animal Physiology, University Potsdam
Alexa Burger: Institute of Molecular Life Sciences, University of Zürich
Stephen Gilbert: Mathematical Cell Physiology, Max Delbrück Centre for Molecular Medicine in the Helmholtz Association
Christian Mosimann: Institute of Molecular Life Sciences, University of Zürich
Salim Abdelilah-Seyfried: Institute for Biochemistry and Biology, Animal Physiology, University Potsdam
Daniela Panáková: Electrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association

DOI: https://doi.org/10.1038/s41467-018-04566-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber formation and looping.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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