Herbicide and Cytogenotoxic Activity of Inclusion Complexes of Psidium gaudichaudianum Leaf Essential Oil and β-Caryophyllene on 2-Hydroxypropyl-β-cyclodextrin

Luiza Alves Mendes; Loren Cristina Vasconcelos; Milene Miranda Praça Fontes; Geisiele Silva Martins; Aline dos Santos Bergamin; Matheus Alves Silva; Rafael Resende Assis Silva; Taíla Veloso de Oliveira; Victor Gomes Lauriano Souza; Marcia Flores da Silva Ferreira; Róbson Ricardo Teixeira; Renata Pereira Lopes

doi:10.3390/molecules28155909

Molecules (Aug 2023)

Herbicide and Cytogenotoxic Activity of Inclusion Complexes of Psidium gaudichaudianum Leaf Essential Oil and β-Caryophyllene on 2-Hydroxypropyl-β-cyclodextrin

Luiza Alves Mendes,
Loren Cristina Vasconcelos,
Milene Miranda Praça Fontes,
Geisiele Silva Martins,
Aline dos Santos Bergamin,
Matheus Alves Silva,
Rafael Resende Assis Silva,
Taíla Veloso de Oliveira,
Victor Gomes Lauriano Souza,
Marcia Flores da Silva Ferreira,
Róbson Ricardo Teixeira,
Renata Pereira Lopes

Affiliations

Luiza Alves Mendes: Departament of Chemistry, Federal University of Viçosa (UFV), Av. Peter Henry Rolfs, s/n, Campus Universitário, Viçosa 36570-000, MG, Brazil
Loren Cristina Vasconcelos: Department of Biology, Federal University of Espírito Santo (UFES), Alto Universitário, s/n, Guararema, Alegre 29500-000, ES, Brazil
Milene Miranda Praça Fontes: Department of Biology, Federal University of Espírito Santo (UFES), Alto Universitário, s/n, Guararema, Alegre 29500-000, ES, Brazil
Geisiele Silva Martins: Department of Biology, Federal University of Espírito Santo (UFES), Alto Universitário, s/n, Guararema, Alegre 29500-000, ES, Brazil
Aline dos Santos Bergamin: Department of Agronomy, Federal University of Espírito Santo (UFES), Alto Universitário, s/n, Guararema, Alegre 29500-000, ES, Brazil
Matheus Alves Silva: Department of Agronomy, Federal University of Espírito Santo (UFES), Alto Universitário, s/n, Guararema, Alegre 29500-000, ES, Brazil
Rafael Resende Assis Silva: Departament of Food Materials Science and Engineering, Federal University of São Carlos (UFSCar), Rod. Washington Luiz, s/n, São Carlos 13565-905, SP, Brazil
Taíla Veloso de Oliveira: Department of Food Technology, Federal University of Viçosa, Viçosa 36570-900, MG, Brazil
Victor Gomes Lauriano Souza: International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal
Marcia Flores da Silva Ferreira: Department of Agronomy, Federal University of Espírito Santo (UFES), Alto Universitário, s/n, Guararema, Alegre 29500-000, ES, Brazil
Róbson Ricardo Teixeira: Departament of Chemistry, Federal University of Viçosa (UFV), Av. Peter Henry Rolfs, s/n, Campus Universitário, Viçosa 36570-000, MG, Brazil
Renata Pereira Lopes: Departament of Chemistry, Federal University of Viçosa (UFV), Av. Peter Henry Rolfs, s/n, Campus Universitário, Viçosa 36570-000, MG, Brazil

DOI: https://doi.org/10.3390/molecules28155909
Journal volume & issue: Vol. 28, no. 15
p. 5909

Abstract

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The present investigation aimed to develop inclusion complexes (ICs) from Psidium gaudichaudianum (GAU) essential oil (EO) and its major compound β-caryophyllene (β-CAR), and to evaluate their herbicidal (against Lolium multiflorum and Bidens pilosa) and cytogenotoxic (on Lactuca sativa) activities. The ICs were obtained using 2-hydroxypropyl-β-cyclodextrin (HPβCD) and they were prepared to avoid or reduce the volatility and degradation of GAU EO and β-CAR. The ICs obtained showed a complexation efficiency of 91.5 and 83.9% for GAU EO and β-CAR, respectively. The IC of GAU EO at a concentration of 3000 µg mL−1 displayed a significant effect against weed species B. pilosa and L. multiflorum. However, the β-CAR IC at a concentration of 3000 µg mL−1 was effective only on L. multiflorum. In addition, the cytogenotoxic activity evaluation revealed that there was a reduction in the mitotic index and an increase in chromosomal abnormalities. The produced ICs were able to protect the EO and β-CAR from volatility and degradation, with a high thermal stability, and they also enabled the solubilization of the EO and β-CAR in water without the addition of an organic solvent. Therefore, it is possible to indicate the obtained products as potential candidates for commercial exploration since the ICs allow the complexed EO to exhibit a more stable chemical constitution than pure EO under storage conditions.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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