Interpretation of plasma amino acid profile using multiple marker approach

Abstract

In the analysis of plasma amino acid profile in a group of patients with left ventricular outflow tract pathology (n = 151) increased levels of serine, alanine, arginine, and lysine has been found. These metabolic shifts can be linked with the development of circulatory deficiency and mitochondrial dysfunction. The differentiation of the reference values intervals helps in the assessment of individual amino acid profiles.

Keywords

• метаболомика
• аминокислоты
• митохондриальная дисфункция
• metabolomics
• amino acids
• mitochondrial dysfunction