Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies

Pedro M. Folegatti; Amy Flaxman; Daniel Jenkin; Rebecca Makinson; Lucy Kingham-Page; Duncan Bellamy; Fernando Ramos Lopez; Jonathan Sheridan; Ian Poulton; Jeremy Aboagye; Nguyen Tran; Celia Mitton; Rachel Roberts; Alison M. Lawrie; Adrian V. S. Hill; Katie J. Ewer; Sarah Gilbert

doi:10.3390/vaccines9030262

Vaccines (Mar 2021)

Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies

Pedro M. Folegatti,
Amy Flaxman,
Daniel Jenkin,
Rebecca Makinson,
Lucy Kingham-Page,
Duncan Bellamy,
Fernando Ramos Lopez,
Jonathan Sheridan,
Ian Poulton,
Jeremy Aboagye,
Nguyen Tran,
Celia Mitton,
Rachel Roberts,
Alison M. Lawrie,
Adrian V. S. Hill,
Katie J. Ewer,
Sarah Gilbert

Affiliations

Pedro M. Folegatti: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Amy Flaxman: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Daniel Jenkin: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Rebecca Makinson: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Lucy Kingham-Page: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Duncan Bellamy: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Fernando Ramos Lopez: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Jonathan Sheridan: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Ian Poulton: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Jeremy Aboagye: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Nguyen Tran: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Celia Mitton: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Rachel Roberts: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Alison M. Lawrie: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Adrian V. S. Hill: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Katie J. Ewer: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
Sarah Gilbert: The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK

DOI: https://doi.org/10.3390/vaccines9030262
Journal volume & issue: Vol. 9, no. 3
p. 262

Abstract

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Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.

Published in Vaccines

ISSN: 2076-393X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/vaccines

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Abstract

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