Nature Communications (May 2019)
Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
- Simon F. Merz,
- Sebastian Korste,
- Lea Bornemann,
- Lars Michel,
- Pia Stock,
- Anthony Squire,
- Camille Soun,
- Daniel R. Engel,
- Julia Detzer,
- Holger Lörchner,
- Dirk M. Hermann,
- Markus Kamler,
- Joachim Klode,
- Ulrike B. Hendgen-Cotta,
- Tienush Rassaf,
- Matthias Gunzer,
- Matthias Totzeck
Affiliations
- Simon F. Merz
- Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen
- Sebastian Korste
- Department of Cardiology and Vascular Medicine, University Hospital Essen
- Lea Bornemann
- Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen
- Lars Michel
- Department of Cardiology and Vascular Medicine, University Hospital Essen
- Pia Stock
- Department of Cardiology and Vascular Medicine, University Hospital Essen
- Anthony Squire
- Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen
- Camille Soun
- Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen
- Daniel R. Engel
- Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen
- Julia Detzer
- Dept. of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research
- Holger Lörchner
- Dept. of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research
- Dirk M. Hermann
- Department of Neurology, University Hospital Essen
- Markus Kamler
- Department of Thoracic and Cardiovascular Surgery, University Hospital Essen
- Joachim Klode
- Department of Dermatology, Venerology and Allergology, University Hospital Essen
- Ulrike B. Hendgen-Cotta
- Department of Cardiology and Vascular Medicine, University Hospital Essen
- Tienush Rassaf
- Department of Cardiology and Vascular Medicine, University Hospital Essen
- Matthias Gunzer
- Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen
- Matthias Totzeck
- Department of Cardiology and Vascular Medicine, University Hospital Essen
- DOI
- https://doi.org/10.1038/s41467-019-10338-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Detailed characterization of cardiac damage following ischemia/reperfusion injury and detection of occurring inflammatory responses is important for the development of new therapeutic concepts. Here the authors present a method for the three-dimensional investigation of acute and chronic cardiac injury responses using light sheet fluorescence microscopy.
