The Role of Natural Killer Cells and Their Metabolism in HIV-1 Infection

Abstract

Natural killer (NK) cells are multifaceted innate effector cells that critically influence antiviral immunity, and several protective NK cell features that modulate HIV-1 acquisition and viral control have been described. Chronic HIV-1 infection leads to NK cell impairment that has been associated with metabolic dysregulations. Therapeutic approaches targeting cellular immune metabolism represent potential novel interventions to reverse defective NK cell function in people living with HIV.

Keywords

• HIV-1 infection
• innate immunity
• antiviral immunity
• natural killer cells
• immunometabolism
• NK cell metabolism